THE SINGLE BEST STRATEGY TO USE FOR NR1-SITE

Using this strategy, Kalbaugh et al. assigned affinity and efficacy roles to positions from the LBDs of the NR1 and NR2A NMDAR subunits. In situ mutation of residues in direct connection with bound ligand affected both of those efficacy and affinity, whilst positions that stabilize the closed cleft conformation without a immediate ligand conversati